Browsing Department of Chemistry and Biochemistry by Title
Now showing items 122-141 of 247
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Leveraging propargylic frameworks in the total synthesis of natural products containing a 2-aminoimidazole
(2019-08-30)Our group is mainly interested in the total synthesis of marine sponge-derived 2-aminoimidazole-containing alkaloids. A new family of 2-aminoimidazole alkaloids, the Leucetta alkaloids, is a group of >60, 2-aminoimidazole ... -
Light Driven Reduction Of Carbon Dioxide Via Ruthenium Polypyridyl Complexes In The Presence Of A Pyridinium Cocatalyst
The rapid increase in atmospheric carbon dioxide since the industrial revolution is now beginning to cause global climate changes which could adversely affect our planets ecosystem. Nonetheless, our ability to sustain the ... -
LIQUID FLOW MEASUREMENT: FROM INLINE HYDROCEPHALUS SHUNT FLOW MONITOR TO FLOWMETRY IN THE NANOLITER/MINUTE SCALE
(2019-08-13)This dissertation primarily focuses on designing and developing novel sensing strategies and instruments for ultra-low liquid flow measurement. An inline thermal flow sensor based on a single common thermistor has been ... -
LnCrTeO6 (Ln= La, Pr, Nd) octahedral distortions and optical characterization
(2022-08-17)LnCrTeO6 (La, Pr, Nd) compounds are suspected to appear as vibrant blue-green colored materials. LnCrTeO6 (La, Pr, Nd) were synthesized to analyze the local coordination environments of Ln3+, Cr3+, and Te6+ cations. ... -
Long non-coding RNAs in inflammation, macrophage activation, and inflammatory human diseases
(2023-08-28)**Please note that the full text is embargoed until 08/01/2025** Inflammation and immune signaling is central to infection and diseases. Growing evidence suggests that along with protein coding genes, long non-coding RNAs ... -
Mass Spectrometry-based Biomolecular Recognition And Response Factor Investigations Using Electrospray Ionization
(Chemistry & Biochemistry, 2008-09-17)Integrins are transmembrane proteins found in almost all cells. They play vital roles in many biological processes, such as angiogenesis and signal transduction, through their interactions with different extracellular ... -
MECHANISM AND USE OF PAIRED ION ELECTROSPRAY IONIZATION (PIESI) IN HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY (HPLC-MS) FOR SENSITIVE ANALYSIS OF ANIONIC COMPOUNDS
(2016-04-18)In recent years, the paired ion electrospray ionization (PIESI) technique has been emerged as a promising alternative to overcome the inherent low sensitivity of negative ESI-MS. The current research focused on the further ... -
Mechanistic And Kinetic Studies On F420H2: NADP+ Oxidoreductase From Archeoglobus fulgidus
F420H2: NADP+ Oxidoreductase (Fno) is an F420 cofactor dependent enzyme that catalyzes the reversible reduction of NADP+ to NADPH by transferring a hydride from the reduced F420 cofactor. F420 cofactor is an essential ... -
MECHANISTIC STUDIES OF F420-DEPENDENT ENZYMES BY KINETIC ANALYSIS
(2021-08-10)The focus of this research is to elucidate the catalytic mechanism of F420-dependent enzymes using F420-dependent glucose-6-phosphate dehydrogenase (FGD) from Mycobacteria tuberculosis (Mtb) and F420H2:NADP+ Oxidoreductase ... -
Mechanistic Study Of Cysteine Dioxygenase, A Non-heme Mononuclear Iron Enzyme
(Chemistry & Biochemistry, 2014-09-17)Cysteine dioxygenase (CDO) is an non-heme mononuclear iron enzymes that catalyzes the O2-dependent oxidation of L-cysteine (Cys) to produce cysteine sulfinic acid (CSA). CDO controls cysteine levels in cells and is a ... -
MECHANISTIC STUDY OF THE INHIBITION OF RHO GTPASE-MEDIATED METASTASIS
(2019-01-04)The Ras superfamily of small GTPases are monomeric proteins that bind guanine nucleotides, and regulate many cellular signaling pathways. They function as molecular switches by shuttling between active GTP-bound and inactive ... -
Method development for qualification and quantification of cannabinoids and terpenes in extracts by Gas chromatography-mass spectrometry
(2016-07-19)Cannabinoids are a class of chemical compounds that act on cannabinoid receptors in cells. These receptors have different kinds of ligands, including endocannabinoids (produced in the body by humans and animals), ... -
Mixed Lineage Leukemia Histone Methylases In Gene Expresion And Cancer
(Chemistry & Biochemistry, 2009-09-16)Histone methyl-transferases (HMTs) are key enzymes that post-translationally methylate nuclear histone proteins and play critical roles in gene expression, epigenetic regulation and diseases in eukaryotic organisms. Mixed ... -
Mixed Lineage Leukemia Histone Methylases In Hormonal Regulation Of HOX Genes And Their Disruption By Endocrine Disrupting Chemicals
(Chemistry & Biochemistry, 2014-03-10)Homeobox (HOX) genes are highly conserved family of genes that play vital roles during cell differentiation and embryogenesis. Of the 39 HOX genes present in human, HOXC6 is a critical players in mammary gland development, ... -
Mixed Lineage Luekemia Histone Methyltransferases In Hormonal Regulation Of HOXB9 And Target Gene Regulation
(Chemistry & Biochemistry, 2014-09-17)Homeobox gene (HOX) genes are evolutionary conserved genes that play important roles in cell differentiation, cell proliferation and embryogenesis. HOX genes bind to the DNA via their homeodomain and act as transcription ... -
Modeling ETR1 with Isolable Coinage Metal Complexes Supported by Partially Fluorinated, and Methylated Scorpionates
Ethylene is a small molecule that functions as a plant hormone that is closely associated with several vital plant functions ranging from germination, shoot and root growth, sex expression, fruit ripening, senescence and ... -
Molecular dynamics simulations of the adenylate kinase enzyme and its mutant states
(2022-12-19)Adenylate kinase (AK) is a small, monomeric enzyme present across all domains of life. It is responsible for maintaining homeostasis of an intracellular adenylate pool and catalyzes a reversible transfer of the phosphoryl ... -
Molecular Engineered Myoglobin With Unnatural Amino Acids As A Peroxidase
(Chemistry & Biochemistry, 2013-03-20)Myoglobin (Mb) has been used as a model system to mimic other biologically important heme proteins like cytochrome P450 due to its ability to prepare mixed ligand complexes with different valencies, such as ferric, ferrous ... -
Multinuclear copper(I) and silver(I) pyrazolates: synthesis, luminescence, and catalysis
(2021-12-08)Copper and silver pyrazolate complexes have numerous fascinating properties such as luminescence, catalytic ability, and complexation with small molecules. Using both more widely studied non-fluorinated pyrazolates and ... -
Multiply Charged Cationic Pairing Agents For Trace Analysis Of Anionic Species By Electrospray Ionization Mass Spectrometry
(Chemistry & Biochemistry, 2008-04-22)Electrospray ionization is one of the most broadly useful and successful approaches for coupling high performance liquid chromatography to mass spectrometry. Most of the research in electrospray ionization mass spectrometry ...