Browsing PhD Dissertations - DO NOT EDIT by Author "Heo, Jongyun"
Now showing items 1-4 of 4
-
DETERMINATION OF THE KINETIC ROLES OF THE MEMBRANE IN THE CATALYSIS OF RASGEFS BY USING AN ENGINEERED MODEL PROTEIN
Hoang, Hanh My; 0000-0003-4176-4448 (2021-08-10)Ras guanine nucleotide exchange factors (RasGEFs), which include Son of Sevenless (SOS), Ras Guanine Nucleotide Releasing Protein (RasGRP), and Ras Guanine Nucleotide Releasing Factor (RasGRF), catalyze nucleotide exchange ... -
MECHANISTIC STUDY OF THE INHIBITION OF RHO GTPASE-MEDIATED METASTASIS
Umutesi, Hope Gloria (2019-01-04)The Ras superfamily of small GTPases are monomeric proteins that bind guanine nucleotides, and regulate many cellular signaling pathways. They function as molecular switches by shuttling between active GTP-bound and inactive ... -
RENEWED SIGNIFICANCE OF RAS GTPASES
Wey, MichaelThe Ras superfamily of GTPases act as molecular switches and play a critical role in intracellular signal transduction. These GTPases cycle between an active GTP- bound form and an inactive GDP-bound form to regulate a ... -
Spectroscopic and mechanistic investigation of the enzyme mercaptopropionic acid dioxygenase (MDO), the role of the conserved outer-sphere 'catalytic triad' in directing promiscuous substrate-specificity
Sardar, Sinjinee (2018-05-16)Mercaptopropionate dioxygenase (MDO) from Aztobacter Vinelandii is a non-heme mononuclear iron enzyme that catalyzes the oxygen dependent conversion of 3-mercaptopropionic acid (3mpa) to produce 3-sulfinopropinioic acid ...