Browsing Department of Bioengineering by Title
Now showing items 48-67 of 338
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Decreased Expression Of Microtubules In Confined Microenvironments Leads To A Reduced Effect Of Paclitaxel On Breast Cancer Cells
(Biomedical Engineering, 2014-12)Despite the current medical options available to patients, cancer cells frequently remain after treatment and metastasize. This is particularly significant because secondary cancers account for 90% of cancer-related ... -
Design And Construction Of A Fast Spectrometer For Fourier Domain Optical Coherence Tomography
(Biomedical Engineering, 2007-08-23)A fast spectrometer capable of operating at 27.8 KHz is designed and calibrated to work in the wavelength range of 700-900 nm, to perform Fourier Domain Optical Coherence Tomography (FD-OCT). The OCT system is based on ... -
DESIGN AND DEVELOPMENT OF REAL-TIME SINGLE AND DUAL-WAVELENGTH DCS SYSTEMS TO STUDY SKELETAL MUSCLE BLOOD PERFUSION AND OXYGEN METABOLISM
The aim of this study was to utilize Diffused Correlation Spectroscopy (DCS) to design and develop real-time single and dual wavelength systems and assess the physiological impacts of exercises on blood perfusion. The study ... -
DESIGN, DEVELOPMENT, AND VALIDATION OF A NOVEL OPTICAL IMAGING DEVICE FOR BIOMEDICAL APPLICATIONS
(2019-07-31)Fluorescence and luminescence imaging are two promising optical techniques for diagnosing a variety of critical pathologies in vivo, including wound healing, inflammation, and vascular diseases. Despite this, there is a ... -
Design, Fabrication And Evaluation Of A Novel Microfluidic Based In Vitro Cell Migration Assay
(Biomedical Engineering, 2014-09-17)Microfabrication and microfluidic devices have been recognized as potential platforms for cell-based and drug screening studies. Human glioblastoma multiforme (hGBM) cells migrate inside the central nervous system (CNS) ... -
Designing and advancing contrast agents for ultrasound-switchable fluorescence imaging
(2021-12-09)Fluorescence imaging is a remarkable tool for molecular targeting and multicolor imaging, but it suffers from poor resolution in centimeters-deep tissues. The recently developed ultrasound-switchable fluorescence (USF) ... -
Detecting Clinical Biomarkers Using Diffusion Tensor Imaging
(Biomedical Engineering, 2012-07-25)Diffusion tensor imaging (DTI), a modality of MRI that measures water diffusion properties noninvasively, is highly sensitive to subtle structural changes of white matter. It provides a unique and noninvasive method for ... -
Detection of Molecular Biomarkers involved in the Induction of EMT, migration and invasion, and drug resistance in breast cancer cells in 3D confinement
(2018-09-17)Standard-of-care regimes for cancer treatment have become more effective and sophisticated over the last decade due to research developments which facilitate specific targeting of treatments to certain cancers, and the ... -
Detection Of Positive Cancer Margins Intra-operatively During Nephrectomy And Prostatectomy Using Optical Reflectance Spectroscopy
(Biomedical Engineering, 2007-09-17)In recent years optical spectroscopies have become the basis for popular research activity directed towards the development of novel, noninvasive technologies for tissue diagnostics. The motivation for my research was to ... -
Detection Of Sleep Disordered Breathing Using Electroencephalography
(Biomedical Engineering, 2007-08-23)This study investigates the application of Electroencephalography (EEG) to detect Sleep disordered breathing (SDB) using power spectral analysis. A preliminary study was performed on 13 subjects (ages: 49.08 ± 8.82) ... -
Determining The Flow Characteristics Of A Perfusion Device For Donor Heart Transport
(Biomedical Engineering, 2008-08-08)Current technology has limits organ transport for transplantation to static storage, thereby reducing the reasonable distance of travel. Continuous machine perfusion has been proposed as a viable alternative to improving ... -
DEVELOPMENT AND INVESTIGATION OF FLUORESCENCE IMAGING PROBES
(2019-09-03)Fluorescence imaging has attracted much attention due to high sensitivity, spatial and temporal resolution, and fast acquisition time, for imaging biomolecular processes and for diagnosis of diseases such as cancer in early ... -
Development Of A Broadband Multi-channel NIRS System For Quantifying Absolute Concentrations Of Hemoglobin Derivatives And Reduced Scattering Coefficients
(Biomedical Engineering, 2008-08-08)Near infrared spectroscopy (NIRS) has been widely applied to investigate hemoglobin oxygenations of muscles, brain and breast tumors. Steady state reflectance techniques developed previously have been restricted to ... -
Development Of A Measurement System For Quantifying Ultrasound Field Distribution Of Different Transducers
(Biomedical Engineering, 2014-03-10)Ultrasound has been widely used in many fields, such as nondestructive examination and medical imaging. Ultrasound is mostly characterized by its pressure and, dynamic pressure wave can be considered to be the foundation ... -
Development Of A Model To Simulate The Single-limb Stance Phase Of Walking To Determine The Limits Of Stability
(Biomedical Engineering, 2013-07-22)Falls during walking are the primary cause of injuries for older persons and present a high associated cost to society due to the resulting treatment. Hence, the control of balance while moving is an essential issue ... -
Development Of A Multi-channel Handheld Probe Designed For Near Infrared Spectroscopy And An Exploration Into Its Clinical Applications
(Biomedical Engineering, 2007-08-23)Near Infrared (NIR) spectroscopy and imaging has become popular in research fields for the past 2 decades. My research focuses on the development of a handheld, multi-channel, multi-separation probe for the low-cost, ... -
Development of Algorithms to Analyze Electrogastrography (EGG) for Neonatal Gastrointestinal Development and Electroencephalography (EEG) for Effects of LED-based Pre-frontal Light Stimulation
(2022-05-17)Algorithm development, and biological signal processing are the key components for new applications of successful medical diagnosis that can provide physiological and functional information to better understand human ... -
DEVELOPMENT OF AN IN VITRO TBI MODELS AND VALIDATION OF NANODELIVERY FOR RESTORATION OF DISRUPTED BRAIN ENDOTHELIUM
(2019-09-06)Blast-induced traumatic brain injury (bTBI) is a serious concern among military personnel and their families. Although the mechanisms responsible for disruption to the brain are not well understood, the development of ... -
Development Of An In-vitro Assay For Neurotrophin-induced Segregation Of Nociceptive And Proprioceptive Sensory Axons
(Biomedical Engineering, 2007-08-23)Peripheral nerves have the capacity for regeneration and if properly repaired, axon extensions can regenerate even across gaps caused by peripheral nerve loss. Complete functional recovery after gap injury repair remains ... -
Development Of An Optical Spectroscopic Method To Detect Neurohemodynamic Changes Induced By Pain In Rats
(Biomedical Engineering, 2010-03-03)In my optical spectroscopy study, multi-channel, thin optical probes with short source-detector separation have been implemented, calibrated, and used along with a multi-channel spectrometer as a quantitative technique to ...