Browsing Dissertations & Theses by Title
Now showing items 1-20 of 301
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3-dimensional Scanning And Reconstruction Using A Modified HRT-RCM Corneal Confocal Microscope
(Biomedical Engineering, 2012-04-11)The HRT II - Rostock Corneal Module (HRT II-RCM) provides excellent resolution, contrast and optical sectioning capability for cornea imaging. It offers the most detailed views of cornea structure and pathology. However, ... -
5 cm Gap Injury Repair: Growth Factor Support And Functional Analysis In A Rabbit Common Peroneal Nerve Model
(Biomedical Engineering, 12-10-2012)Nerve conduits have shown to successfully bridge nerve gaps of ≤ 3 cm; however repair of longer, mixed or motor nerve gaps still remains a clinical challenge. In order to study regeneration techniques in clinically relevant ... -
A Comparative Biomechanical Investigation of Porcine Neonatal and Adult Left Ventricular Tissues
(2023-05-22)A current trend in cardiac muscle regeneration and repair is to recreate the biophysical and biomechanical environment of the neonatal hearts, which has been shown to promote cardiac regeneration. This translational need ... -
A Liver-Kidney Biosubsystem
(2017-05-04)Each year many patients die waiting for a transplant organ to become available. Increasing the available number of transplant organs would save lives. The donor pool could be expanded if organs which are considered to be ... -
Advances In Helical Stent Design And Fabrication: Studies Of Stent Thermal Treatment, Stent Mechanical Properties, And Stent Interactions With A Simulated Plaque-laden Artery
(Biomedical Engineering, 2010-11-01)Advancements in processing biomaterials have lead to the development of bioresorbable PLLA drug-loaded stents with different geometric configurations. To further advance the technology, systematic studies have been carried ... -
ADVANCING THE RADIATION ONCOLOGY CLINIC WITH MOTION MANAGEMENT AND AUTOMATIC TREATMENT PLANNING
(2022-06-09)The leading cause of premature death (death under the age of 70) is cancer. The top five cancers for both male and female are: lung, colorectum, pancreas, breast cancer, and prostate. In 2020 there was an estimated 19.3 ... -
AN ACTOMYOSIN DRIVEN, PRESSURE BASED ADHESION MODEL OF CONFINED GLIOBLASTOMA MULTIFORME CELL MIGRATION
(2016-05-13)Glioblastoma multiforme (GBM) is the most aggressive and common form of glial tumors arising in the support cells of the brain. Cell migration plays a critical role in undermining the surgical resection of tumors. ... -
An Enhancement of Light Reflectance Spectroscopy as A Modality for the Detection of Positive Surgical Margins in Radical Prostatectomy
(2018-08-29)Light Reflectance Spectroscopy (LRS) is an imaging method that has shown increasingly promising evidence in its ability to detect various forms of cancer tissues. Our previous studies have illustrated the LRS modality’s ... -
An In vitro 3D Model to Investigate IOL: Posterior Lens Capsule Interactions on Lens Epithelial Cell Responses
(2023-01-18)**Please note that the full text is embargoed until 12/19/2024** ABSTRACT: Posterior Capsule Opacification (PCO) is the most common complication associated with Intraocular Lens (IOL) implantation. The disease is caused ... -
AN IN VITRO MODEL TO STUDY THE ROLE OF IOL: LENS CAPSULE INTERACTIONS IN POSTERIOR CAPSULE OPACIFICATION
(2021-05-05)Posterior capsule opacification (PCO) is the most common complication associated with intraocular lens (IOL) implantation. Unfortunately, current in vitro models cannot be used to assess the potential of PCO due to their ... -
AN INVESTIGATION OF THE RELATION BETWEEN SLEEP DISORDERED BREATHING AND COGNITIVE FUNCTION
(2015-12-16)Obstructive sleep apnea (OSA) is one of the most prevalent sleep related breathing disorders, with an estimated amount 17% of affected adults in the U.S. Research has linked OSA to mood and cognitive disorders, including ... -
Analysis Of Oxygen Uptake During Blood Flow Through A Rectangular Microchannel: A Two Phase Eulerian Model With Oxygen-hemoglobin Reaction
(Biomedical Engineering, 2009-09-16)The evolution of oxygenator design has culminated in the current strategy of utilizing micro-porous membranes to separate blood and oxygen phases while utilizing extra-luminal blood flow orientations to promote passive and ... -
Analysis Of The Dynamics Of Vasomotion Using Laser Doppler Flow
(Biomedical Engineering, 2007-08-23)Vasomotion is a phenomenon caused by changes in the diameters of blood vessels. It is due to the contractile activity of small arteries and arterioles resulting in periodic changes of blood flow in the skin. These flow ... -
Antimicrobial Properties Of Citric Acid Based Polymers
(Biomedical Engineering, 2013-03-20)A series of citric acid derived polymers synthesized in our lab were investigated and compared for their physiochemical and antimicrobial properties. We selected citric acid based polymers since citric acid is a product ... -
Application Of Scanning Correlation Spectroscopy Techniques To Quantify DNA Double Strand Break Repair Kinetics In The Living Cell After Exposure To γ-rays And Radiomimetic Chemicals
(Biomedical Engineering, 2013-03-20)The kinetics of most proteins involved in DNA damage sensing, signaling and repair following ionizing radiation exposure cannot be quantified by current live cell fluorescence microscopy methods. This is because most of ... -
APPLICATION OF TISSUE ENGINEERING TECHNIQUES FOR TREATING CARTILAGE INJURY AND DIAGNOSING CANCER METASTASIS
(2019-08-05)This study focuses on the application of tissue engineering techniques for the diagnosis of cancer metastasis, cartilage regeneration, and modeling of lymph node metastasis. Chapter 1 is an overview of tissue engineering ... -
Attenuation Based Quantification Of Interstitial Lung Disease Using High Resolution Computed Tomography And Correlation With Pulmonary Function Tests
(Biomedical Engineering, 2010-11-01)Interstitial lung disease (ILD) is a chronic and progressive pulmonary disease of the lung parenchyma resulting in fibrotic scar formation of the pulmonary alveoli. The pathologic changes in the lung result in restrictive ... -
Automated Quantification Of White Matter Hyperintensity Burden Using Mprage And Flair Images From A Large Population
(Biomedical Engineering, 2009-09-16)White Matter Hyperintensity(WMH) burden, as observed in T2 and proton weighted MR images, is associated with several health factors such as decreased cognitive ability, hypertension, diabetes and cerebrovascular disease. ... -
Biaxial Investigation Of Periosteal Mechanics
(Biomedical Engineering, 2009-09-16)Limb lengthening procedures are used commonly to correct limb length discrepancies. Current methods in limb lengthening require a distraction of 1 mm per day using an external fixation device. Although the underlying ... -
Biaxial Mechanical Characterization Of Porcine Periosteum
(Biomedical Engineering, 2008-08-08)Periosteum is multipotent tissue responsible for cortical bone deposition and is important in fracture repair. Research indicates the periosteum is mediated by similar mechanical signals to those that mediate bone growth ...