High-resolution imaging in a deep turbid medium based on an ultrasound-switchable fluorescence technique
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Date
2012Author
Nguyen, Kytai Truong
Yuan, Baohong
Liu, Yuan
Alexandrakis, Georgios
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**Please note that the full text is embargoed** ABSTRACT: The spatial resolution of fluorescence imaging techniques in deep optically turbid media such as
tissues is limited by photon diffusion. To break the diffusion limit and achieve high-resolution and
deep-tissue fluorescence imaging, a fundamentally different method was demonstrated based on a
concept of ultrasound-switchable fluorescence. The results showed that a small fluorescent tube
with a diameter of 180 lm at a depth of 20mm in an optical scattering medium (l0
s 3:2 and
la 0:026 cm 1) can be clearly imaged with a size of 260 lm. The depth-to-resolution ratio is
shown to be about one order of magnitude better than other deep-tissue fluorescence imaging
techniques.