Department of Bioengineering: Recent submissions
Now showing items 1-20 of 338
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Quantification and identification of neuro-electrophysiological markers and brain network for biomedical applications
(2023-08-23)Electroencephalogram (EEG) can detect and monitor neuro-electrophysiological signals in the human brain, including assessing brain function in newborns at risk of neurological injury and healthy adults undergoing intervention ... -
DESIGN AND DEVELOPMENT OF REAL-TIME SINGLE AND DUAL-WAVELENGTH DCS SYSTEMS TO STUDY SKELETAL MUSCLE BLOOD PERFUSION AND OXYGEN METABOLISM
The aim of this study was to utilize Diffused Correlation Spectroscopy (DCS) to design and develop real-time single and dual wavelength systems and assess the physiological impacts of exercises on blood perfusion. The study ... -
LIGHT REFLECTANCE SPECTROSCOPY FOR THE DETECTION OF POSITIVE SURGICAL MARGIN OF PROSTATE CANCER
During a radical prostatectomy in the operating room, there exists a certain degree of risks of a surgical positive margin of prostate cancer. Positive surgical margins are defined as cancer that has spread beyond the ... -
Development of Mussel Inspired Nanocomposite Adhesives for Biomedical Applications
Popular bioadhesives, such as fibrin, cyanoacrylate and albumin–glutaraldehyde-based materials, have been applied for clinical applications in wound healing, drug delivery, and bone and soft tissue engineering; however, ... -
NATURALLY-DERIVED EXTRACELLULAR MATRIX MATERIALS FOR MENISCUS REPAIR AND REGENERATION
Human meniscus plays critical roles in a knee joint by transmitting weight-bearing force, absorbing shock, and stabilizing the knee joint capsule. Meniscal injuries are mainly caused by sports-related activities and ... -
NOVEL NANOPARTICLES TO STIMULATE THERAPEUTIC ANGIOGENESIS FOR THE TREATMENT OF PERIPHERAL ARTERIAL DISEASES
(2022-08-15)Peripheral arterial disease (PAD) is a severe impairment of arterial vessels resulting in obstruction of normal blood flow in the legs, leading to acute or chronic lower limb ischemia and subsequently high morbidity and ... -
An In vitro 3D Model to Investigate IOL: Posterior Lens Capsule Interactions on Lens Epithelial Cell Responses
(2023-01-18)**Please note that the full text is embargoed until 12/19/2024** ABSTRACT: Posterior Capsule Opacification (PCO) is the most common complication associated with Intraocular Lens (IOL) implantation. The disease is caused ... -
Engineering Enzymatic Pathways in the Gut Microbiome to Control Dietary Isoflavone Metabolism
(2022-05-17)**Please note that the full text is embargoed until 5/17/2024** ABSTRACT: Observing how plasmids persist within the gut can help us understand how newly introduced genes are transmitted within the gut microbiome. I sought ... -
Designing and advancing contrast agents for ultrasound-switchable fluorescence imaging
(2021-12-09)Fluorescence imaging is a remarkable tool for molecular targeting and multicolor imaging, but it suffers from poor resolution in centimeters-deep tissues. The recently developed ultrasound-switchable fluorescence (USF) ... -
Development of Algorithms to Analyze Electrogastrography (EGG) for Neonatal Gastrointestinal Development and Electroencephalography (EEG) for Effects of LED-based Pre-frontal Light Stimulation
(2022-05-17)Algorithm development, and biological signal processing are the key components for new applications of successful medical diagnosis that can provide physiological and functional information to better understand human ... -
TARGETED DRUG-LOADED NANOPARTICLE SYSTEM (TDNPS) TO AMELIORATE AND TREAT IDIOPATHIC LUNG FIBROSIS
(2022-12-19)Idiopathic pulmonary fibrosis (IPF) is a fatal progressive disease with a dismal prognosis and 3-5 years of survival. Up to date, there are no effective treatments, and a few current therapies that do not ameliorate the ... -
NOVEL NANOCOMPOSITES FOR THE TREATMENT OF LUNG INFECTIONS
(2022-05-17)Lung infections, especially lower respiratory tract infections and their associated pneumonias, are one of the leading causes of death, accounting for more than 4 million fatalities every year worldwide. Bacterial pathogens ... -
PORCINE NEONATAL HEART EXTRACELLULAR MATRIX AS A REGENERATION PLATFORM
(2021-08-16)Each year, an estimated 620,000 Americans have new heart attack and suffer from myocardial infarction (MI) that results in massive heart cell death and decrease in heart function. Various therapeutic strategies, such as ... -
BIOMECHANICAL STUDIES OF DEVELOPING ZEBRAFISH HEART IN-VIVO
(2021-05-05)The heart is an electrically controlled mechanical pump that provides the cardiac output required by the body to function properly and flexibly adapts to changing demand and working conditions. In vertebrate embryos, the ... -
A Comparative Biomechanical Investigation of Porcine Neonatal and Adult Left Ventricular Tissues
(2023-05-22)A current trend in cardiac muscle regeneration and repair is to recreate the biophysical and biomechanical environment of the neonatal hearts, which has been shown to promote cardiac regeneration. This translational need ... -
Physiological Analyses of Broadband Near-Infrared Spectroscopy and Electrophysiological Measurements in vivo for Biomedical Applications
(2023-05-08)My thesis concerns analysis of data from optical and electrophysiological measurement tools for calculate potential biomarkers in three biomedical applications: (1) the gastrointestinal immaturity of infants of different ... -
Engineering Elastic and Functional Electrospun Nano-Fibers for Potential Heart Repair
(2022-08-17)In the United States and around the world, cardiovascular disease (CVD) has been one of the main causes of death since 1921, responsible for approximately 1 in 4 deaths domestically. Myocardial infarction (MI), or commonly ... -
ADVANCING THE RADIATION ONCOLOGY CLINIC WITH MOTION MANAGEMENT AND AUTOMATIC TREATMENT PLANNING
(2022-06-09)The leading cause of premature death (death under the age of 70) is cancer. The top five cancers for both male and female are: lung, colorectum, pancreas, breast cancer, and prostate. In 2020 there was an estimated 19.3 ... -
Electrophysiological, Hemodynamic, and Metabolic Effects of Transcranial Photobiomodulation (tPBM) on Topographical and Physiological Connectivity in the Human Brain
(2022-08-17)Transcranial photobiomodulation (tPBM) targets the human brain with near-infrared (NIR) light and is shown to affect human cognitive performance and neural electrophysiological activity as well as concentration changes of ... -
Nanoparticle-Mediated Controlled Myocardial Drug Delivery: A New Treatment for Hypertrophic Cardiomyopathy
(2020-09-04)Hypertrophic cardiomyopathy (HCM) is a genetic disease of the sarcomere, resulting in overgrowth of the septum that separates the left and right ventricles. HCM can affect as many as 1/200 people, making it the most common ...