Hanli Liu, Ph.D.
http://hdl.handle.net/10106/26292
2024-03-29T11:09:29ZWavelet coherence analysis of dynamic cerebral autoregulation in neonatal hypoxic–ischemic encephalopathy
http://hdl.handle.net/10106/26479
Wavelet coherence analysis of dynamic cerebral autoregulation in neonatal hypoxic–ischemic encephalopathy
Tian, Fenghua; Tarumi, Takashi; Liu, Hanli; Zhang, Rong; Chalak, Lina
Cerebral autoregulation represents the physiological mechanisms that keep brain perfusion relatively constant in
the face of changes in blood pressure and thus plays an essential role in normal brain function. This study assessed
cerebral autoregulation in nine newborns with moderate-to-severe hypoxic–ischemic encephalopathy (HIE).
These neonates received hypothermic therapy during the first 72 h of life while mean arterial pressure (MAP)
and cerebral tissue oxygenation saturation (SctO2) were continuously recorded. Wavelet coherence analysis,
which is a time-frequency domain approach, was used to characterize the dynamic relationship between spontaneous oscillations in MAP and SctO2. Wavelet-based metrics of phase, coherence and gain were derived for
quantitative evaluation of cerebral autoregulation. We found cerebral autoregulation in neonates with HIE was
time-scale-dependent in nature. Specifically, the spontaneous changes in MAP and SctO2 had in-phase coherence
at time scales of less than 80 min (b0.0002 Hz in frequency), whereas they showed anti-phase coherence at time
scales of around 2.5 h (~0.0001 Hz in frequency). Both the in-phase and anti-phase coherence appeared to be related to worse clinical outcomes. These findings suggest the potential clinical use of wavelet coherence analysis to
assess dynamic cerebral autoregulation in neonatal HIE during hypothermia.
2016-01-25T00:00:00ZTranscranial Laser Stimulation Improves Human Cerebral Oxygenation
http://hdl.handle.net/10106/26476
Transcranial Laser Stimulation Improves Human Cerebral Oxygenation
Tian, Fenghua; Hase, Snehal Niwrutti; Gonzalez-Lima, F.; Liu, Hanli
Transcranial laser stimulation of the brain with near-infrared light is a novel form
of non-invasive photobiomodulation or low-level laser
therapy (LLLT) that has shown therapeutic potential in
a variety of neurological and psychological conditions.
Understanding of its neurophysiological effects is essential
for mechanistic study and treatment evaluation. This
study investigated how transcranial laser stimulation
influences cerebral hemodynamics and oxygenation in
the human brain in vivo using functional near-infrared
spectroscopy (fNIRS).
0012-01-01T00:00:00ZSparsity enhanced spatial resolution and depth localization in diffuse optical tomography
http://hdl.handle.net/10106/26475
Sparsity enhanced spatial resolution and depth localization in diffuse optical tomography
Kavuri, Venkaiah C.; Lin, Zi-Jing; Tian, Fenghua; Liu, Hanli
2012-05-01T00:00:00ZQuantification of functional near infrared spectroscopy to assess cortical reorganization in children with cerebral palsy
http://hdl.handle.net/10106/26474
Quantification of functional near infrared spectroscopy to assess cortical reorganization in children with cerebral palsy
Tian, Fenghua; Delgado, Mauricio R.; Dhamne, Sameer C.; Khan, Bilal; Alexandrakis, George; Romero, Mario I.; Smith, Linsley; Reid, Dahlia; Clegg, Nancy J.; Liu, Hanli
2010-11-22T00:00:00Z