Publications - DO NOT EDIThttp://hdl.handle.net/10106/263372024-03-29T11:39:29Z2024-03-29T11:39:29ZPrefrontal responses to digit span memory phases in patients with post-traumatic stress disorder (PTSD): A functional near infrared spectroscopy studyTian, FenghuaYennu, AmarnathSmith-Osborne, AlexaGonzalez-Lima, F.North, Carol S.Liu, Hanlihttp://hdl.handle.net/10106/264712024-01-02T17:48:12Z2014-01-01T00:00:00ZPrefrontal responses to digit span memory phases in patients with post-traumatic stress disorder (PTSD): A functional near infrared spectroscopy study
Tian, Fenghua; Yennu, Amarnath; Smith-Osborne, Alexa; Gonzalez-Lima, F.; North, Carol S.; Liu, Hanli
Neuroimaging studies of post-traumatic stress disorder (PTSD)-related memory impairments have consistently implicated abnormal activities in the frontal and parietal lobes. However, most studies have used
block designs and could not dissociate the multiple phases of working memory. In this study, the involvement of the prefrontal cortex in working memory phases was assessed among veterans with PTSD and age-/
gender-matched healthy controls. Multichannel functional near infrared spectroscopy (fNIRS) was utilized
to measure prefrontal cortex hemodynamic activations during memory of neutral (i.e., not trauma-related)
forward and backward digit span tasks. An event-related experimental design was utilized to dissociate the
different phases (i.e., encoding, maintenance and retrieval) of working memory. The healthy controls showed
robust hemodynamic activations during the encoding and retrieval processes. In contrast, the veterans with
PTSD were found to have activations during the encoding process, but followed by distinct deactivations
during the retrieval process. The PTSD participants, but not the controls, appeared to suppress prefrontal
activity during memory retrieval. This deactivation was more pronounced in the right dorsolateral prefrontal
cortex during the retrieval phase. These deactivations in PTSD patients might implicate an active inhibition
of dorsolateral prefrontal neural activity during retrieval of working memory.
2014-01-01T00:00:00ZEquine Therapy in the Treatment of Female Eating DisorderCumella, EdwardLutter, Carolyn BoydSmith-Osborne, AlexaKally, Zinahttp://hdl.handle.net/10106/263402024-01-05T16:45:09ZEquine Therapy in the Treatment of Female Eating Disorder
Cumella, Edward; Lutter, Carolyn Boyd; Smith-Osborne, Alexa; Kally, Zina
**Please note that the full text is embargoed** ABSTRACT: The article describes the preconditions and develops the hypothesis concerning the Equine
therapy (EQT) is commonly used in the treatment of eating disorder (ED) inpatients, yet studies
of its efficacy are lacking. This treatment outcome study therefore compares the efficacy of a
standardized inpatient treatment protocol to standard treatment plus EQT among ED subjects.
The sample include 72 women ED inpatients between ages 18 and 49, diagnosed with anorexia
and bulimia nervosa and eating disorder not otherwise specified. We assesse specific ED and
common co-occurring symptoms hypothesized in the literature as amenable to treatment with
EQT, including drive for thinness, impaired self-efficacy, interpersonal distrust, impulse dysregulation, depressed mood, and anxiety. Multiple regression analyses controlling for initial symptom
severity and quantity of standardized treatment received find that the amount of time patients
engaged in EQT in addition to standardized treatment produces statistically significant and
clinically meaningful reductions in the six ED symptoms measured. We summarize hypotheses
regarding the therapeutic mechanisms that may account for these significant effects of EQT.
The incremental value of EQT in addition to standardized inpatient ED treatment in reducing
critical ED symptoms may warrant additional investigation into EQT with this patient population.
Prefrontal responses to Stroop tasks in subjects with post-traumatic stress disorder assessed by functional near infrared spectroscopyYennu, AmarnathTian, FenghuaSmith-Osborne, AlexaGatchel, Robert J.Woon, Fu LyeLiu, Hanlihttp://hdl.handle.net/10106/262952023-11-21T18:58:15Z0007-01-01T00:00:00ZPrefrontal responses to Stroop tasks in subjects with post-traumatic stress disorder assessed by functional near infrared spectroscopy
Yennu, Amarnath; Tian, Fenghua; Smith-Osborne, Alexa; Gatchel, Robert J.; Woon, Fu Lye; Liu, Hanli
0007-01-01T00:00:00Z